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Propofol induces the dysregulation of <t>miRNA</t> profiles in 7-day-old mouse hippocampi. ( A ) Expression profile of altered miRNAs detected using <t>RT-qPCR.</t> miRNA expression in the propofol-treated group is expressed as percent of intralipid controls. ( B ) Heatmap showing the profiles of 18 differentially expressed miRNAs between intralipid and propofol-treated mouse hippocampi. The red, green, and black signals refer to the relatively higher, lower, and baseline levels of miRNA expression compared with the control group, respectively. Expression level of each sample for individual miRNAs was displayed as percentage of the control average. n = 4; p < 0.05.
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Propofol induces the dysregulation of <t>miRNA</t> profiles in 7-day-old mouse hippocampi. ( A ) Expression profile of altered miRNAs detected using <t>RT-qPCR.</t> miRNA expression in the propofol-treated group is expressed as percent of intralipid controls. ( B ) Heatmap showing the profiles of 18 differentially expressed miRNAs between intralipid and propofol-treated mouse hippocampi. The red, green, and black signals refer to the relatively higher, lower, and baseline levels of miRNA expression compared with the control group, respectively. Expression level of each sample for individual miRNAs was displayed as percentage of the control average. n = 4; p < 0.05.
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Dezhou Deyao Pharmaceutical Co Ltd testicular mirna profiles
Propofol induces the dysregulation of <t>miRNA</t> profiles in 7-day-old mouse hippocampi. ( A ) Expression profile of altered miRNAs detected using <t>RT-qPCR.</t> miRNA expression in the propofol-treated group is expressed as percent of intralipid controls. ( B ) Heatmap showing the profiles of 18 differentially expressed miRNAs between intralipid and propofol-treated mouse hippocampi. The red, green, and black signals refer to the relatively higher, lower, and baseline levels of miRNA expression compared with the control group, respectively. Expression level of each sample for individual miRNAs was displayed as percentage of the control average. n = 4; p < 0.05.
Testicular Mirna Profiles, supplied by Dezhou Deyao Pharmaceutical Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Propofol induces the dysregulation of miRNA profiles in 7-day-old mouse hippocampi. ( A ) Expression profile of altered miRNAs detected using RT-qPCR. miRNA expression in the propofol-treated group is expressed as percent of intralipid controls. ( B ) Heatmap showing the profiles of 18 differentially expressed miRNAs between intralipid and propofol-treated mouse hippocampi. The red, green, and black signals refer to the relatively higher, lower, and baseline levels of miRNA expression compared with the control group, respectively. Expression level of each sample for individual miRNAs was displayed as percentage of the control average. n = 4; p < 0.05.

Journal: Scientific Reports

Article Title: Signaling network between the dysregulated expression of microRNAs and mRNAs in propofol-induced developmental neurotoxicity in mice

doi: 10.1038/s41598-018-32474-3

Figure Lengend Snippet: Propofol induces the dysregulation of miRNA profiles in 7-day-old mouse hippocampi. ( A ) Expression profile of altered miRNAs detected using RT-qPCR. miRNA expression in the propofol-treated group is expressed as percent of intralipid controls. ( B ) Heatmap showing the profiles of 18 differentially expressed miRNAs between intralipid and propofol-treated mouse hippocampi. The red, green, and black signals refer to the relatively higher, lower, and baseline levels of miRNA expression compared with the control group, respectively. Expression level of each sample for individual miRNAs was displayed as percentage of the control average. n = 4; p < 0.05.

Article Snippet: miRNA profiling assay was performed using mouse miRNA qPCR profiling array (Applied Biological Materials Inc./Qiagen). cDNA of hippocampi was used as templates for analysis of total 726 mature mouse miRNAs by RT-qPCR.

Techniques: Expressing, Quantitative RT-PCR

Propofol exposure results in dysregulated mRNA/miRNA profiles and interacting signaling in the P60 mouse hippocampus. ( A ) Hierarchical clustering of differentially expressed mRNA genes between control and propofol treated mouse hippocampi on P60 was displayed by heatmap (p < 0.05). The red signal denotes high relative expression and the green signal denotes low relative expression. ( B ) Expression profile of altered miRNAs detected using RT-qPCR (p < 0.05). miRNA expression in the propofol-treated group is expressed as percent of intralipid controls. ( C ) Venn diagrams illustrating numbers of differentially expressed mRNAs and miRNAs shared between P7 and P60. An overlap of 2 differentially expressed mRNAs but no differentially expressed common miRNAs between P7 and P60 mouse hippocampi were identified.

Journal: Scientific Reports

Article Title: Signaling network between the dysregulated expression of microRNAs and mRNAs in propofol-induced developmental neurotoxicity in mice

doi: 10.1038/s41598-018-32474-3

Figure Lengend Snippet: Propofol exposure results in dysregulated mRNA/miRNA profiles and interacting signaling in the P60 mouse hippocampus. ( A ) Hierarchical clustering of differentially expressed mRNA genes between control and propofol treated mouse hippocampi on P60 was displayed by heatmap (p < 0.05). The red signal denotes high relative expression and the green signal denotes low relative expression. ( B ) Expression profile of altered miRNAs detected using RT-qPCR (p < 0.05). miRNA expression in the propofol-treated group is expressed as percent of intralipid controls. ( C ) Venn diagrams illustrating numbers of differentially expressed mRNAs and miRNAs shared between P7 and P60. An overlap of 2 differentially expressed mRNAs but no differentially expressed common miRNAs between P7 and P60 mouse hippocampi were identified.

Article Snippet: miRNA profiling assay was performed using mouse miRNA qPCR profiling array (Applied Biological Materials Inc./Qiagen). cDNA of hippocampi was used as templates for analysis of total 726 mature mouse miRNAs by RT-qPCR.

Techniques: Expressing, Quantitative RT-PCR